Focal Adhesion Kinase: An Old Protein with New Roles
Atul Kumar Pandey, Sonal Somvanshi and Vivek Pratap Singh
DOI : 10.3844/ojbsci.2012.11.14
OnLine Journal of Biological Sciences
Volume 12, Issue 1
Focal adhesion kinase, FAK is a tyrosine kinase which is prominently localized to focal adhesions and therefore its name, is an indispensable protein in integrin signaling. Since the discovery of FAK, this tyrosine kinase had been shown to regulate a variety of cell behavior like cell migration, proliferation, apoptosis and metastasis which makes this molecule at a centre stage of cell and developmental biology research. We want to take this opportunity to briefly review the current state of knowledge about FAK and why FAK was so important in cell migration, apoptosis, cardiovascular and metastatic research. Since the FAK signalling was very crucial for normal cellular development and cell physiology and since its deregulation prompts the oneset of a variety of diseases like cancer and cardiovascular diseases, an updated knowledge about its signalling mechanism and how FAK interacts with other signalling molecules can not only offer newer understanding in this field but also attract new methods and pathways to explore and investigate its biology, which can further open new avenues in anticancer research targetting FAK.
© 2012 Atul Kumar Pandey, Sonal Somvanshi and Vivek Pratap Singh. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.