Research Article Open Access

Influence of Helium-Neon Laser Photostimulation on Excision Wound Healing in Wistar Rats

B. S. Nayak1, A. Maiya2 and P. Kumar1
  • 1 Kasturba Medical College, India
  • 2 College of Allied Health Sciences, India

Abstract

The importance of laser photostimulation is now accepted generally but the laser light facilitates wound healing and tissue repair remains poorly understood. So we have examined the hypothesis that the laser photo stimulation can enhances the collagen production in excision wounds using excision wound model in Wister rat model. The circular wounds were created on the dorsum of the back of the animals. The animals were divided into two groups. The experimental group (n = 12) wound was treated with 632.8 nm He-Ne laser at a dose of 2.1J cm-2 for five days a week until the complete healing. The control group was sham irradiated. The parameters studied were wound area, period of epithelization and hydroxyproline. Significant increase in the hydroxyproline content (p<0.001) and reduction in the wound size (p<0.001) was observed in study group when compared to controls. The significant epithelization (p<0.001) was noticed. The experimental wounds were, on average, fully healed by the 15th day, whereas the control group healed, on average by 22nd day. Wound contraction together with the hydroxyproline and experimental observations suggested that low intensity Helium-Neon laser photo stimulation facilitates the tissue repair process by accelerating collagen production in chronic wounds.

OnLine Journal of Biological Sciences
Volume 7 No. 2, 2007, 89-92

DOI: https://doi.org/10.3844/ojbsci.2007.89.92

Submitted On: 11 February 2008 Published On: 31 December 2007

How to Cite: Nayak, B. S., Maiya, A. & Kumar, P. (2007). Influence of Helium-Neon Laser Photostimulation on Excision Wound Healing in Wistar Rats. OnLine Journal of Biological Sciences, 7(2), 89-92. https://doi.org/10.3844/ojbsci.2007.89.92

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Keywords

  • Laser photostimulation
  • wound healing
  • hydroxyproline
  • autoCAD RL, 14
  • experimental observation and excision wound