Current Research in Drug Discovery

Determination of Optimum Values of Descriptors to Set Filters for Synthetic Tri-Pyrrole Derivatives (Prodiginines) Against Multi Drug Resistant Strain of Plasmodium Falciparum

Vijay H. Masand, Devidas T. Mahajan, Eslam Pourbasheer, Taibi Ben Hadda, Harsh Chauhan, J. M. Gajbhiye and A. M. Alafeefy

DOI : 10.3844/crddsp.2014.51.59

Current Research in Drug Discovery

Volume 1, Issue 2

Pages 51-59

Abstract

In the present study, we have carried out extensive non-linear Quantitative-Structure Activity Relationship (QSAR) analysis to correlate in vitro anti-malarial activity against multi drug resistant strain of Plasmodium falciparum. Forty-three synthetic prodiginines with different structural features were used for their potential antimalarial activity. Linear, bilinear, biexponential and parabolic equations were developed. These equations were compared to determine the optimum values of descriptors for very useful and easily interpretable descriptors. The optimum values of these descriptors could be helpful in finding and optimizing a good lead compound. Obtained correlations reveal that various factors like lipophilicity, molecular weight and number of bonds have non-linear relation with the anti-malarial activity.

Copyright

© 2014 Vijay H. Masand, Devidas T. Mahajan, Eslam Pourbasheer, Taibi Ben Hadda, Harsh Chauhan, J. M. Gajbhiye and A. M. Alafeefy. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.