Physiological Study on the Effect of Acalypha wilkesiana Leaves Extract on Streptozotocin-Induced Experimental Diabetes in Male Mice

Atef M. Al-Attar

American Medical Journal
DOI: 10.3844/amjsp.2010.51.58
Volume 1, Issue 1
Pages 51-58

Abstract

Problem statement: Diabetes mellitus is a chronic disease that causes serious health complications and it is now one of the most common non-communicable diseases globally. It is the fourth or fifth leading cause of death in most high-income countries and there is substantial evidence that it is epidemic in many economically developing and newly industrialized nations. Recently, there has been a growing interest in antidiabetic agents from natural products especially those derived from plants. The antidiabetic agents have been focused on plants used in traditional medicine because that may be a better treatment than currently used synthetic drugs. Approach: The influence of Acalypha wilkesiana leaves extract on the levels of serum glucose, triglycerides, cholesterol, sodium (Na), potassium (K) and Calcium (Ca) was investigated using Streptozotocin (STZ)-induced diabetic mice. Diabetes was induced in male albino mice by single intraperitoneal injection of STZ (60 mg kg1 body weight). The experimental animals were divided into four groups. The first group was untreated and served as normal control. The mice of second group were used as diabetic control group. The diabetic mice of third group were treated orally with A. wilkesiana leaves extract for 30 days. The normal mice of fourth group were treated orally with A. wilkesiana leaves extract at the same dose given to third group. Results: The diabetic mice showed significant increases in the levels of serum glucose, triglycerides, cholesterol and Na after 10, 20 and 30 days. Also, the level of K was statistically increased after 20 and 30 days, while the level of Ca was significantly elevated after 30 days. The diabetic mice given A. wilkesiana leaves extract showed significant decreases in the levels of serum glucose, cholesterol and K. Insignificant alterations in the values of serum triglycerides, Na and Ca were noted in diabetic mice treated with leaves extract at all periods of experiment. Conclusion/Recommendations: These new data indicate that A. wilkesiana represents an effective antihyperglycemic, antihyperlipidemic adjunct and ameliorative role on electrolytes disturbances for the treatment of diabetes and a potential source of discovery of new therapeutic agent.

Chamaemelum nobile L. Aqueous Extract Represses Endogenous Glucose Production and Improves Insulin Sensitivity in Streptozotocin-induced Diabetic Mice

Citation:
Lemhadri, Ahmed, R. Burcelin, T. Sulpice and M. Eddouks, 2007. Chamaemelum nobile L. Aqueous Extract Represses Endogenous Glucose Production and Improves Insulin Sensitivity in Streptozotocin-induced Diabetic Mice. Am. J. Pharmacol. Toxicol., 2: 116-122.
DOI: 10.3844/ajptsp.2007.116.122

Adiponectin mRNA Expression in the Cat (Felis domesticus)

Citation:
Lusby, A.L., S.A. Kania, J.W. Bartges and C.A. Kirk, 2010. Adiponectin mRNA Expression in the Cat (Felis domesticus). Am. J. Anim. Vet. Sci., 5: 228-232.
DOI: 10.3844/ajavsp.2010.228.232

Anti-hyperglycaemic and Anti-obesity Effects of Capparis spinosa and Chamaemelum nobile Aqueous Extracts in HFD Mice

Citation:
Lemhadri, A., M. Eddouks, T. Sulpice and R. Burcelin, 2007. Anti-hyperglycaemic and Anti-obesity Effects of Capparis spinosa and Chamaemelum nobile Aqueous Extracts in HFD Mice. Am. J. Pharmacol. Toxicol., 2: 106-110.
DOI: 10.3844/ajptsp.2007.106.110

Antibiotic Susceptibility and Immunomodulatory Potential of Chosen Bacterial Pathogens

Citation:
Sujatha, M., P. Dhasarathan and B. Karthick, 2010. Antibiotic Susceptibility and Immunomodulatory Potential of Chosen Bacterial Pathogens. Am. J. Immunol., 6: 15-19.
DOI: 10.3844/ajisp.2010.15.19

Biochemical and Immunological Study on the Effects of Barley and its Components as Hypoglycemic Agents in Diabetic Rats

Citation:
Yousef, M.I., M. Haroun, M.H. El-Masry and R.E. Ateia, 2006. Biochemical and Immunological Study on the Effects of Barley and its Components as Hypoglycemic Agents in Diabetic Rats. Am. J. Biochem. Biotechnol., 2: 1-8.
DOI: 10.3844/ajbbsp.2006.1.8

Concomitant Down Regulation of Glycolytic Enzymes, Upregulation of Gluconeogenic Enzymes and Potential Hepato-Nephro-Protective Effects Following the Chronic Administration of the Hypoglycemic, Insulinotropic Citrullus colocynthis Pulp Extract

Citation:
Dallak, M., N. Bashir, M. Abbas, R.E.M. Haidara and M. Khalil et al., 2009. Concomitant Down Regulation of Glycolytic Enzymes, Upregulation of Gluconeogenic Enzymes and Potential Hepato-Nephro-Protective Effects Following the Chronic Administration of the Hypoglycemic, Insulinotropic Citrullus colocynthis Pulp Extract. Am. J. Biochem. Biotechnol., 5: 153-161.
DOI: 10.3844/ajbbsp.2009.153.161

Effect of Hydro-Alcoholic Extract of Cucurbita Maxima, Fruit Juice and Glibenclamide on Blood Glucose in Diabetic Rats

Citation:
Lal, V.K., P.P. Gupta, A. Pandey and P. Tripathi, 2011. Effect of hydro-alcoholic extract of cucurbita maxima, fruit juice and glibenclamide on blood glucose in diabetic rats. Am. J. Pharmacol. Toxicol., 6: 84-87.
DOI: 10.3844/ajptsp.2011.84.87

Effect of Phenylbutazone on Pentylenetetrazole-Induced Seizure in Mice

Citation:
Mirhadi, K., 2011. Effect of phenylbutazone on pentylenetetrazole-induced seizure in mice. Am. J. Anim. Vet. Sci., 6: 135-145.
DOI: 10.3844/ajavsp.2011.135.145

Effects of D- and L-Glucose and Mannitol on Retinal Capillary Cells: Inhibition by Nanomolar Aminoguanidine

Citation:
Yu, Y., W. Li, B. Wojciechowski, A.J. Jenkins and T.J. Lyons, 2007. Effects of D- and L-Glucose and Mannitol on Retinal Capillary Cells: Inhibition by Nanomolar Aminoguanidine. Am. J. Pharmacol. Toxicol., 2: 148-158.
DOI: 10.3844/ajptsp.2007.148.158

Induction of Micronuclei in Mice Lymphocytes Exposed to Microwave and Toluene

Citation:
Mortazavi, S.B., A. Safari, A. Khavanin, A. Kazemnejad and S.M. Moazzeni et al 2005. Induction of Micronuclei in Mice Lymphocytes Exposed to Microwave and Toluene. Am. J. Applied Sci., 2: 1321-1324.
DOI: 10.3844/ajassp.2005.1321.1324

Protective Effect of Enicostemma littorale Blume on Rat Model of Diabetic Neuropathy

Citation:
Bhatt, N.M., S. Barua and S. Gupta, 2009. Protective Effect of Enicostemma littorale Blume on Rat Model of Diabetic Neuropathy. Am. J. Infect. Dis., 5: 99-105.
DOI: 10.3844/ajidsp.2009.99.105

Sorbitol-Induced Diabetic-Like Retinal Lesions in Rats: Microscopic Study

Citation:
Ramadan, G.A., 2007. Sorbitol-Induced Diabetic-Like Retinal Lesions in Rats: Microscopic Study. Am. J. Pharmacol. Toxicol., 2: 89-97.
DOI: 10.3844/ajptsp.2007.89.97

The Effect of Citrullus colocynthis Pulp Extract on the Liver of Diabetic Rats a Light and Scanning Electron Microscopic Study

Citation:
Khalil, M., G. Mohamed, M. Dallak, F. Al-Hashem and H. Sakr et al., The Effect of Citrullus colocynthis Pulp Extract on the Liver of Diabetic Rats a Light and Scanning Electron Microscopic Study. Am. J. Biochem. Biotechnol., 6: 155-163.
DOI: 10.3844/ajbbsp.2010.155.163

The Effect of Vitamin C on the Metabolic Parameters of Experimental Diabetes Mellitus

Citation:
Al-Shamsi, M., A. Amin and E. Adeghate, 2007. The Effect of Vitamin C on the Metabolic Parameters of Experimental Diabetes Mellitus. Am. J. Pharmacol. Toxicol., 2: 4-9.
DOI: 10.3844/ajptsp.2007.4.9

Total Level of Serum Homocysteine in Males and Females with Coronary Heart Disease of Different Age Groups

Citation:
Mohammad, F.I., S. Awawdeh, A. Saleh and N.A. Bashir, 2010. Total Level of Serum Homocysteine in Males and Females with Coronary Heart Disease of Different Age Groups. Am. J. Biochem. Biotechnol., 6: 116-119.
DOI: 10.3844/ajbbsp.2010.116.119

Citation

Al-Attar, A.M., 2010. Physiological Study on the Effect of Acalypha wilkesiana Leaves Extract on Streptozotocin-Induced Experimental Diabetes in Male Mice. Am. Med. J., 1: 51-58.
DOI: 10.3844/amjsp.2010.51.58
URL: http://thescipub.com/abstract/10.3844/amjsp.2010.51.58

Physiological Study on the Effect of Acalypha wilkesiana Leaves Extract on Streptozotocin-Induced Experimental Diabetes in Male Mice

Abstract

Related Articles

Citation