Green Tea Treatment Attenuates Oxidative Damage and Neuromotor Deficit Induced by an Experimental Model of Intracerebral Hemorrhage in Rats
Mauren Assis Souza, Caroline Dalla Colletta Altermann, Alexandre dos Santos Martins, Priscila Marques Sosa, Cristiano Chiapinotto Spiazzi, Francieli Weber Santos and Pamela Billig Mello-Carpes
DOI : 10.3844/amjnsp.2016.11.18
Volume 7, 2016
The present study shows the neuroprotective effect of green tea supplementation (GT; Camellia sinensis) in a model of Intracerebral Hemorrhage (ICH) in rats. ICH was induced by intra-striatum collagenase infusion in male Wistar rats. GT (400 mg Kg-1) was administered via gavage for 10 days after ICH. We assessed the effect of GT on neuromotor recovery and oxidative damage. Our results show that ICH causes neuromotor deficits observed by Neurological Deficit Scale (NDS), Open Field (OF) and Rotarod (RR). GT treatment attenuates this deficit on day 3 for NDS and OF and on day 7 for RR. Also, ICH increases Reactive Oxygen Species (ROS) production and lipid peroxidation, what is not observed in ICH + GT group. Currently, there are no effective pharmacologic or non-pharmacologic neuroprotective treatments for ICH. Nutritional interventions that help on its outcome are important, since they are generally accessible and have few side effects.
© 2016 Mauren Assis Souza, Caroline Dalla Colletta Altermann, Alexandre dos Santos Martins, Priscila Marques Sosa, Cristiano Chiapinotto Spiazzi, Francieli Weber Santos and Pamela Billig Mello-Carpes. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.