Assessment of Quality of Life, Anxiety and Depression in Children with Turner Syndrome: A Case-Control Study
Khaled A. Abdel Baseer, Abdulrahman Abdullah Al-Atram, Khaled Saad, Ahmed M. Ali and Amira A. El-Houfey
DOI : 10.3844/amjnsp.2015.8.12
Volume 6, Issue 1
Turner syndrome is a genetic disorder that affects only females and is caused by the loss of the whole or a part of the X-chromosome. The aim of this study was to assess the quality of life and frequency of anxiety and depression in a cohort of Egyptian children with Turner Syndrome (TS) diagnosed in Assiut university hospitals, Assiut, Egypt. In a case-control study; 40 females with Turner Syndrome (TS), aged 6-16 years, diagnosed in Assiut university hospitals, Upper Egypt, were compared to 40 age- matched apparent healthy girls as controls. They were subjected to full history taking, thorough clinical examination and assessment of pediatric quality of life; we used pediatric anxiety and depression scores. For cognitive assessment, Health-Related Quality of Life (HR-QOL) and psychological evaluation of anxiety and depression; we used the “Children Depression Scale” (CDI), “Children Anxiety Scale” Wechsler Intelligence Scale for Children (WISC) and SF-36 by trained psychiatrists blind to the study. Our study revealed Children Anxiety Scale scores ranged from 13-41 for patients with TS and 5-23 for controls. The mean anxiety scores were significantly higher in TS patients as compared to controls (p<0.001), (27.32±7.1 versus 15.2±2.9). In addition, we found CDI scores ranged from 38-70 for patients and 31-56 for controls. Mean depression scores were significantly higher in TS patients as compared to controls (p<0.001), (54.7±8.8 versus 36.8±9.9). The physical and mental component summary scores of HR-QOL were lower in TS patients when compared to controls. We concluded that female children with TS experience significant problems with HR-QOL, anxiety and depression, which need thorough psychiatric evaluation and rapid intervention of these patients.
© 2015 Khaled A. Abdel Baseer, Abdulrahman Abdullah Al-Atram, Khaled Saad, Ahmed M. Ali and Amira A. El-Houfey. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.