The HCV Replicase Interactome
Antonio Mas, Pilar Clemente-Casares, Eugenio RamÃrez and Rosario Sabariegos
DOI : 10.3844/ajvsp.2016.8.14
American Journal of Virology
Volume 5, Issue 1
Viruses are obligate parasites and can only reproduce within host cells because they lack metabolic pathways to complete their replication cycles. Host factors required in viral replication are mainly those involved in lipid metabolism, cell cycle control and apoptosis, cell-to-cell interactions, immune system regulation, etc. Several inhibitors targeting viral polymerases have been designed. However, the rapid appearance of resistant mutants, as a direct consequence of the viral population structure, diminishes the efficacy of this kind of molecules. To elude the rapid loss of treatment efficiency due to the appearance of resistance mutations, cellular factors have been proposed as a promising therapeutic target to inhibit RNA(+) virus replication. In this review, we focus on those interactions between host factors and HCV replicase, to modulate either cellular metabolism or HCV polymerase activity.
© 2016 Antonio Mas, Pilar Clemente-Casares, Eugenio RamÃrez and Rosario Sabariegos. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.