Assessment of Neuropharmacological Activities of Terminalia Chebula in Rats
Wathita Phachonpai, Jintanaporn Wattanathorn, Terdthai Tong-un, Chonlathip Thipkaew, Nongnut Uabundit, Wipawee Thukhammee and Supaporn Muchimapura
DOI : 10.3844/ajptsp.2012.41.48
American Journal of Pharmacology and Toxicology
Volume 7, Issue 2
Problem statement: Oxidative stress has been implicated in the pathophysiology of many neurodegenerative diseases such as Alzheimers Disease (AD). In traditional practices of Ayurvedic medicine, numerous herbs have been used to treat cognitive disorders. Terminalia Chebula (Combretaceae; TC), is a well-known Ayurvedic herbal remedy which possesses an antioxidant activity. The scientific literature strongly supports its in vitro exerted acetylcholinesterase inhibitory and has suggested developing this herb as a potential in the treatment of AD, However, the in vivo neurophamacological activities of this plant have never been studied. Approach: Adult male Sprague-Dawley rats were orally given the different doses of aqueous extracts of TC (10, 20 and 40 mg kg-1) once daily at a period of 2 weeks. The series of established neuropharmacological tests including elevated plus maze, forced swimming, open field and water maze tests were assessed after single administration, 1 and 2 weeks of treatment. Results: TC at a dose of 40 mg kg-1 treated rats exhibited a significant cognitive enhancing effect at all treatment duration. Unfortunately, this substance failed to show dose dependant manner and the other effects. Conclusion: With the above data, it can then be primarily concluded that aqueous extracts of TC should be further investigated about possible active ingredients and developed in line of other anti-Alzheimer herbal drugs or herbal brain booster.
© 2012 Wathita Phachonpai, Jintanaporn Wattanathorn, Terdthai Tong-un, Chonlathip Thipkaew, Nongnut Uabundit, Wipawee Thukhammee and Supaporn Muchimapura. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.