Bilirubin Lowering Potential of Annona muricata (Linn.) In Temporary Jaundiced Rats
Fareed K.N. Arthur, Eric Woode, Ebenezer O. Terlabi and Christopher Larbie
DOI : 10.3844/ajptsp.2012.33.40
American Journal of Pharmacology and Toxicology
Volume 7, 2012
Problem statement: Annona muricata is used in Ghanaian traditional medicine for the treatment of jaundice. Work done has demonstrated A. muricata to be effective in treating carbon tetrachloride-and acetaminophen-induced hepatic damage, hepatic jaundice and toxicologically safe up to 1000 mg kg-1 in animals. Current study evaluated the bilirubin-lowering potential of A. muricata aqueous extract in phenylhydrazine-(40 mg kg-1) induced jaundice in adult rats. Approach: Jaundice was assessed by measuring the levels of total bilirubin and direct bilirubin in phenylhydrazine-treated animals with or without drug treatment with curative, prophylactic study and in animals with reduced liver capacity. Results: Phenylhydrazine induced jaundice in animals from 1.50 ?mol L-1±0.00 total bilirubin in normal animals up to 29.25 ?mol L-1±2.21 in animals with reduced liver capacity. The hyperbilirubinaemia were restored close to normal levels in animals treated with A. muricata aqueous extract at 50 and 400 mg kg-1. Total bilirubin level was reduced to 6.22 ?mol L-1± 0.27 at 50 mg, 5.68 ?mol L-1±0.36 at 400 mg kg-1 and 7.94 ?mol L-1±0.79 with Silymarin, significantly lower (p<0.001) compared with the vehicle group (16.90 ?mol L-1±2.21) maintained with distilled water. Conclusion: Therefore, A. muricata aqueous extract can be used to reduce bilirubin concentration in jaundiced subjects.
© 2012 Fareed K.N. Arthur, Eric Woode, Ebenezer O. Terlabi and Christopher Larbie. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.