American Journal of Pharmacology and Toxicology

Electroanalytical Determination of Doripenem using a Screen-Printed Electrode

Nora H. Al-Shaalan

DOI : 10.3844/ajptsp.2012.1.7

American Journal of Pharmacology and Toxicology

Volume 7, Issue 1

Pages 1-7

Abstract

Problem statement: The performance characteristics of Sensitive Screen-Printed (SPE) and Carbon Paste (CPE) electrodes were investigated for the Determination of Doripenem (DP) in pure, pharmaceutical preparations and biological fluids. Approach: The proposed electrodes is characterized in terms of plasticizer type, response time, pH and temperature. Results: The two electrodes showed nearly Nernstian behaviours over the concentration range of of 2×10−4-5×10−2 mol/l of the drug with slopes of 58 and 57 mV/decade for SPE and CPE electrodes, respectively. The electrodes exhibited good selectivity for DP with respect to a large number of inorganic cations and organic substances present in the biological fluids. The method was precise, as shown by the mean recoveries of 99.49-100 and 98.49-99.49% with mean relative standard deviations 0.38-0.78 and 0.60-0.90% for SPE and CPE electrodes, respectively. Conclusion: Doripenem was determined successfully in pure solutions, in vials or in biological fluids using the standard addition and potentiometric titration methods.

Copyright

© 2012 Nora H. Al-Shaalan. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.