Reversal of Dexamethasone Depressant Action in Wound Healing by Ficus Benghalensis L. Roots
Krishna Murti and Upendra Kumar
DOI : 10.3844/ajptsp.2011.68.75
American Journal of Pharmacology and Toxicology
Volume 6, 2011
Problem statement: Ficus benghalensis is widely used plant world wide traditionally as well as scientifically. It has a wide uses in various medical ailments. As a part of pharmacological evaluations, we have carried out wound healing activity specially in dexamethasone depressed healing conditions. Approach: Wound healing activity was established by two medels namely incision and excision. Results: The roots of Ficus benghalensis clearly reverted the antihealing in presence of dexamethasone treated animals. It happened through increase in breaking strength in incision model and increase in percentage wound contraction and reduction in period of epithelialization. Conclusion: Presence of various chemical constituents in the roots of Ficus benghalensis specially saponins, flavanoids, taannins and alkaloids were responsible for antagonizing the antihealing effect of dexamethasone treated animals.
© 2011 Krishna Murti and Upendra Kumar. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.