American Journal of Pharmacology and Toxicology

Antimicrobial and Wound Healing Potentials of Vitis Vitigenia Leaves

Krishna Murti, Manish Kaushik, Aditi Kaushik and Deepika Paliwal

DOI : 10.3844/ajptsp.2011.119.123

American Journal of Pharmacology and Toxicology

Volume 6, Issue 4

Pages 119-123

Abstract

Problem statement: The investigation for possible antimicrobial and wound healing activity of ethanolic and aqueous extracts of V. Vitigenia L. leaves were performed. The antimicrobial activity of extract was studied against the 8 bacterial and 2 fungal strains using agar cup plate method. Approach: The wound healing effect of both the extract of V. Vitigenia L. leaves were evaluated by incision and excision model in rats. The incision model was assessed by the breaking strength and excision model by % wound contraction and period of Epithelialization. Results: The results showed that both the extracts exhibited significant antimicrobial activity against all the tested microorganisms and have significant wound healing activity as evident from the breaking strength; % wound contraction and period of epithelialization. Conclusion: Therefore, the present study provides a scientific rationale for the traditional use of V. Vitigenia L. in the management of wounds.

Copyright

© 2011 Krishna Murti, Manish Kaushik, Aditi Kaushik and Deepika Paliwal. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.