American Journal of Pharmacology and Toxicology

Interaction of Aqueous Extract of Trigonella Foenum-Graecum Seeds with Glibenclamide in Streptozotocin Induced Diabetic Rats

V. K. Lal, P. P. Gupta, P. Tripathi and A. Pandey

DOI : 10.3844/ajptsp.2011.102.106

American Journal of Pharmacology and Toxicology

Volume 6, Issue 4

Pages 102-106


Problem statement: Interaction between herbs and drugs may increase or decrease the pharmacological or toxicological effects of either component. Herb traditionally used to decrease glucose concentrations in diabetes could theoretically precipitate hypoglycaemia if taken in combination with conventional drugs. Approach: The present study was undertaken to determine the interaction of Glibenclamide, a Sulphonylurea with Trigonella foenum-graecum seed extract, an herbal drug widely used as a antidiabetic agent. The pharmacodynamic interaction was evaluated in streptozotocin induced diabetic rats. Glibenclamide was given orally in two different doses of 0.25 and 0.50 mg kg-1. Trigonella seed extract was administered at a dose of 20 mL kg-1. The blood glucose estimation was carried out. Results: Both glibenclamide and Trigonella seed extract showed hypoglycemic effect. The hypoglycemic effect observed with combination of glibenclamide and Trigonella seed extract was significantly more than either of drug given alone. Conclusion: It is concluded that Trigonella seed extract shows synergistic effect with glibenclamide. This could be important in reducing the dose of glibenclamide to achieve enhanced therapeutic effect with minimum adverse effect.


© 2011 V. K. Lal, P. P. Gupta, P. Tripathi and A. Pandey. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.