Antispasmodic Activity of Persea cordata Vell. Mez. (Lauraceae) Fractions on Guinea Pig Ileum Induced by 5-Hydroxytryptamine and Bradykinin
Júlio A. Zampirolo, Hellen K. Stulzer, Monika Piazzon Tagliari, Valfredo Schlemper and Valdir Cechinel-Filho
DOI : 10.3844/ajptsp.2008.229.233
American Journal of Pharmacology and Toxicology
Volume 3, Issue 4
Problem statement: Persea cordata previously demonstrated antispasmodic action against two neurotransmitters. It is important confirm such action against other neurotransmitters. Approach: Present study described the antispasmodic activity of polar (EtOAc; n-BuOH) and non polar (n-hexane; dichloromethane) fractions from the bark of Persea cordata, against guinea pig ileum contracted by 5-hydroxytryptamine (5-HT) and bradykinin (BK). Results: The results indicated that hexane and dichloromethane fractions caused the most significant relaxant activity against both neurotransmitters tested. Conclusion: The effects seem to be related to the evidenced presence of steroids and terpenes, but additional studies were in progress to identify the active principles of this plant.
© 2008 Júlio A. Zampirolo, Hellen K. Stulzer, Monika Piazzon Tagliari, Valfredo Schlemper and Valdir Cechinel-Filho. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.