American Journal of Pharmacology and Toxicology

Sensitization of Photohemolysis by a New Extraction from Flowers and Aerial Parts of Cichorium Pumilum Jacq: Effects of Inulin and Hydrogen Peroxide

M-Ali H. Al-Akhras, Amr Amin, Karima Mohammad, Fedae AlHaddad and Alaaeldin Hamza

DOI : 10.3844/ajptsp.2007.75.79

American Journal of Pharmacology and Toxicology

Volume 2, Issue 2

Pages 75-79

Abstract

Addition of inulin and hydrogen peroxide to new photosensitizers extracted from the flowers and aerial parts of the chicory (Cichorium Pumilum Jacq) have been investigated. Some of the isolated photosensitizers remain unidentified compounds. Chicory extracts are found to be dependent on light and temperature. Higher photohemolysis rate was noticed under the influence of light as compared to temperature. The effect of H2O2 on phototoxicity reported in this study showed a rapid reduction in the fractional hemolysis percentage at higher temperature. Compared to erythrocytes with higher concentrations and under the influence of solar irradiance 505.29±24.96w/m2, erythrocytes with lower concentrations of inulin and H2O2 were ruptured faster. Samples with 0.95 mg/ml of herb extract and different concentrations of inulin (1mg/ml – 2mg/ml) shows no temperature effects at 40°C in the absent of sunlight.

Copyright

© 2007 M-Ali H. Al-Akhras, Amr Amin, Karima Mohammad, Fedae AlHaddad and Alaaeldin Hamza. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.