American Journal of Pharmacology and Toxicology

Sesame Oil As A Protective Agent Against Doxorubicin Induced Cardio Toxicity In Rat

Kaneez F. Shad, Suhail Al-Salam and Alaaeldin A. Hamza

DOI : 10.3844/ajptsp.2007.159.163

American Journal of Pharmacology and Toxicology

Volume 2, Issue 4

Pages 159-163

Abstract

The therapeutic value of doxorubicin (DXO) as anticancer antibiotic is limited by its cardiotoxicity. This study aimed to investigate the protective effect of sesame oil against DXO-induced cardiotoxicity and oxidative stress. The administration of DXO (20 mg/kg) to Wister male rats, increased serum aspartate aminotransferase and creatine kinase activities (as cardiotoxicity indices) as well as cardiac malondialdehyde and protein carbonyl contents and catalase activity (as markers of oxidative stress). The cardiotoxicity damage in DOX treated rats was accompanied by histo pathological changes such as necrosis and apoptosis in cardiac tissues. These biochemical and histological disturbances were effectively attenuated on pretreatment with sesame oil (5ml/kg). These data suggest that sesame oil may be a suitable cardio protector during DOX treatment.

Copyright

© 2007 Kaneez F. Shad, Suhail Al-Salam and Alaaeldin A. Hamza. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.