Cardiovascular Effect of Capapris spinosa Aqueous Extract in Rats. Part II: Furosemide-like Effect of Capparis spinosa Aqueous Extract in Normal Rats
N.A. Zeggwagh, J. B. Michel, T. Sulpice and T. M. Eddouks
DOI : 10.3844/ajptsp.2007.130.134
American Journal of Pharmacology and Toxicology
Volume 2, Issue 3
The purpose of this study was to examine the diuretic effect of the aqueous extract of Capparis spinosa (Cs) at a dose of 500 mg kg-1 h-1 in normal rats. The aqueous extract was administred intravenously and the diuresis was followed within four hours after starting the treatment. Intravenous administration of aqueous Cs extract produced a significant increase on diuresis (p<0.001) and glomerular filtration rate from the second hour of treatment to the fourth hour (p<0.001). In addition, urinary Na+, Cl- and K + were significantly increased after two hours of Cs perfusion (p<0.01). Furosemide at a dose of 0.1 mg kg-1 h-1 had similar effect when compared to Cs administration. We conclude that the water extract of Cs fruit exhibited a significant diuretic effect accompanied by in crease in Na+, K+ and Cl- urinary excretion in normal rat. This effect amy be mediated via a Furosemide like effect.
© 2007 N.A. Zeggwagh, J. B. Michel, T. Sulpice and T. M. Eddouks. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.