Anti-hyperglycaemic and Anti-obesity Effects of Capparis spinosa and Chamaemelum nobile Aqueous Extracts in HFD Mice
A. Lemhadri, Mohamed Eddouks, Thierry Sulpice and Remy Burcelin
DOI : 10.3844/ajptsp.2007.106.110
American Journal of Pharmacology and Toxicology
Volume 2, Issue 3
This study was undertaken in order to evaluate the possible anti-hyperglycaemic and body weight reducing activities of the aqueous extract of both Capparis spinosa (CS) and Chamaemelum nobile (CN) (20 mg/kg-1). The results demonstrate clearly that repeated oral administration of both CS and CN aqueous extract evoked a potent anti-hyperglycaemic activity in high fat diet (HFD) obese mice. Postprandial hyperglycaemic peaks were significantly lower in plant-treated experimental groups. In other hand, body weight was significantly lower in CS and CN-treated groups when compared to the control one after daily oral administration of CS and CN aqueous extracts for 15 days. We can conclude that these plants evoked potent anti-hyperglycaemic and anti-obesity effects. This fact could support their use by the Moroccan population for diabetes control and treatment.
© 2007 A. Lemhadri, Mohamed Eddouks, Thierry Sulpice and Remy Burcelin. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.