Tacrolimus Dosing Challenges in an African American Child
Teresa V. Lewis, Tracy M. Hagemann and Martin A. Turman
DOI : 10.3844/ajptsp.2006.36.39
American Journal of Pharmacology and Toxicology
Volume 1, Issue 3
It has been suggested that African Americans have decreased effectiveness with immunosuppressive drugs. Data regarding the pharmacokinetics of tacrolimus in African Americans are limited. We present the case of an African American child in whom management of nephrotic syndrome caused by focal segmental glomerulosclerosis has been challenging due to unpredictable patient specific pharmacokinetic disposition of tacrolimus. Racial differences have been documented in literature to have an important impact on the pharmacokinetics and pharmacodynamics of certain drugs. As a result, African American patients may require larger doses or more frequent administration of certain medications to achieve therapeutic efficacy compared to Caucasians and other ethnic groups.
© 2006 Teresa V. Lewis, Tracy M. Hagemann and Martin A. Turman. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.