American Journal of Pharmacology and Toxicology

Stability of Neodymium(III) Complexes of 4-Hydroxycoumarins with Anticoagulant Activity

Irena Kostova and Irina Nikolova

DOI : 10.3844/ajptsp.2006.30.35

American Journal of Pharmacology and Toxicology

Volume 1, Issue 2

Pages 30-35

Abstract

Complexes of neodymium(III) with 4-hydroxy-3-(3-oxo-1-phenylbutyl)-2H-1-benzopyran-2-one, 4-hydroxy-3-[1-(4-chlorophenyl)-3-oxobutyl]-2H-1-benzopyran-2-one and 4-hydroxy-3-[1-(4-nitrophenyl)-3-oxobutyl]-2H-1-benzopyran-2-one were synthesized by mixing of water solutions of neodymium(III) nitrate and the respective ligands, in amounts equal to metal: ligand molar ratio of 1: 3. The complexes were characterized and identified by elemental analysis, conductivity, IR and 1H NMR spectral data. DTA and TGA have been applied to confirm the compositions of the compounds. The formation of the complexes was studied by IR-and 1H-NMR-spectroscopy. The complexation reactions were studied in detail by spectrophotometric method. The stepwise formation of the complexes has been established in the pH region studied. The equilibrium constants for the complexes have been determined. The complexes of neodymium(III) with 4-hydroxy-3-(3-oxo-1-phenylbutyl)-2H-1-benzopyran-2-one, 4-hydroxy-3-[1-(4-chlorophenyl)-3-oxobutyl]-2H-1-benzopyran-2-one and 4-hydroxy-3-[1-(4-nitrophenyl)-3-oxobutyl]-2H-1-benzopyran-2-one were assayed for acute intraperitoneal and per oral toxicity and for influence on blood clotting time.

Copyright

© 2006 Irena Kostova and Irina Nikolova. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.