Serum Adenosine Deaminase Level in Iraqi Women with Toxoplasmosis with a History of Abortion
Ahmed H. AL-Khafaji, Tarik I. AL-Jeboori and Ameena S.M. Juma
DOI : 10.3844/ajmsp.2016.12.17
Current Research in Microbiology
Volume 7, 2016
Sixty women who had abortion were selected for this study. Serum was collected from the women. ELISA test was used to detect anti-Toxoplasma specific antibodies. Those women were divided into three groups according to the presence or absence of specific anti-Toxoplasma antibodies. These groups included the women with IgG (18), the women with IgM (14) and the women with both IgG and IgM (12). The other 16 women had no antibodies against Toxoplasma. Twenty-four healthy-looking women had been selected as controls. Serum was collected from those women and tested for anti-Toxoplasma antibodies. Those that revealed any antibody titer against Toxoplasma were excluded from the study. The activity of ADA was determined in the serum according to the method of Giusti. The mean concentration of ADA in the women who had anti-Toxoplasma IgM antibody was significantly higher (P<0.0001) than that of healthy controls and the women who had IgG, while there was no significant differences between women who had IgG antibody and healthy controls (P>0.05). Since a relationship exists between ADA activity and the cell mediated immune response, this result confirms the fact that Toxoplasma antigen induces T-lymphocytes proliferation.
© 2016 Ahmed H. AL-Khafaji, Tarik I. AL-Jeboori and Ameena S.M. Juma. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.