American Journal of Immunology

Clinical Case Report of a Novel Immunotherapeutic Approach to Autism Spectrum Disorders based on an emulsion of Chondroitin Sulfate, Vitamin D3 and Oleic Acid

Nicola Antonucci, Stefania Pacini and Marco Ruggiero

DOI : 10.3844/ajisp.2017.180.185

American Journal of Immunology

Volume 13, Issue 3

Pages 180-185

Abstract

In this clinical case report we describe the effects associated with the administration of a supplement constituted by chondroitin sulfate, vitamin D3 and oleic acid (Rerum®) on the symptoms of Autism Spectrum Disorders (ASD). 44 patients (11 females and 33 males) were administered this supplement for a period of two months and variations of symptomatology were evaluated by the Clinical Global Impression of Improvement (CGI-I). 32 out of 44 subjects (73%), showed improvements in the two months of observation. In the group of female subjects, 9 out of 11 (81%) showed improvements and, among these, 6 out of 9 (66%) showed moderate to very considerable improvements. In the group of male subjects, 24 out of 33 (73%) showed improvements and, among these, 22 out of 24 (91%) showed moderate to very considerable improvements. We attribute these remarkable results to the effects of the supplement on the endocannabinoid system as it relates to neuro-inflammation and neuro-immune alterations.

Copyright

© 2017 Nicola Antonucci, Stefania Pacini and Marco Ruggiero. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.