Evaluation the Synergistic Effect of High Dose Radiation of Radioiodine on the Immune System Suppressed By Cyclosporine
Mehrosadat Alavi, Mohammad Ali Okhovat, Kourosh Bamdad, Motahareh Motazedian, Fatemeh Ebadi, Ahmad Movahedpour, Faezeh Hekmatara and Mohammad Atefi
DOI : 10.3844/ajisp.2015.85.91
American Journal of Immunology
Volume 11, 2015
Cyclosporine is an immunosuppressant drug and iodine-131 is the diagnostic and therapeutic radioisotope in nuclear medicine. In this study, we aimed to evaluate the synergistic effect of high-dose radiation of radioiodine on the suppression of the immune system of BALB/cmice after receiving cyclosporine. A total of 50 mice BALB/c were randomly divided into two groups (control and test). Then, 50 mg kg-1 body weight cyclosporine was given to both groups. After 24 h, 0.5 mL iodine-131 was given to the test group and in the control group the same volume of normal saline was given. Data analysis was done using SPSS V.20 and p value <0.05 was considered significant. After 30 days of monitoring, only 2 deaths (8%) occurred in the control group, however 16 deaths (64%) were observed in the test group. Statistical analysis of the data indicated that there is a significant relationship (p value <0.0005) between injecting radioiodine and the mortality rate in mice receiving cyclosporine and proves the synergistic effect of these two factors. Based on the results, iodine-131 can be introduced as a stimulating and synergistic factor on the suppression of the immune system of BALB/cmice and subsequent death.
© 2015 Mehrosadat Alavi, Mohammad Ali Okhovat, Kourosh Bamdad, Motahareh Motazedian, Fatemeh Ebadi, Ahmad Movahedpour, Faezeh Hekmatara and Mohammad Atefi. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.