Research Article Open Access

CLINICAL EXPERIENCE OF CANCER IMMUNOTHERAPY INTEGRATED WITH OLEIC ACID COMPLEXED WITH DE-GLYCOSYLATED VITAMIN D BINDING PROTEIN

Emma Ward1, Rodney Smith1, Jacopo J.V. Branca2, David Noakes3, Gabriele Morucci4 and Lynda Thyer1
  • 1 , UK
  • 2 University of Firenze, Italy
  • 3 , Channel Islands
  • 4 University of Firenze, Italy.
American Journal of Immunology
Volume 10 No. 1, 2014, 23-32

DOI: https://doi.org/10.3844/ajisp.2014.23.32

Submitted On: 26 February 2014
Published On: 8 March 2014

How to Cite: Ward, E., Smith, R., Branca, J. J., Noakes, D., Morucci, G. & Thyer, L. (2014). CLINICAL EXPERIENCE OF CANCER IMMUNOTHERAPY INTEGRATED WITH OLEIC ACID COMPLEXED WITH DE-GLYCOSYLATED VITAMIN D BINDING PROTEIN. American Journal of Immunology, 10(1), 23-32. https://doi.org/10.3844/ajisp.2014.23.32

Abstract

Proteins highly represented in milk such as α-lactalbumin and lactoferrin bind Oleic Acid (OA) to form complexes with selective anti-tumor activity. A protein present in milk, colostrum and blood, vitamin D binding protein is the precursor of a potent Macrophage Activating Factor (GcMAF) and in analogy with other OA-protein complexes, we proposed that OA-GcMAF could demonstrate a greater immunotherapeutic activity than that of GcMAF alone. We describe a preliminary experience treating patients with advanced cancers, often labelled as "incurable" with an integrative immunotherapy centred on OA-GcMAF. Patients with advanced cancer were treated at the Immuno Biotech Treatment Centre with OA-GcMAF-based integrative immunotherapy in combination with a very low carbohydrate, high protein diet, fermented milk products containing naturally produced GcMAF, vitamin D3 and low-dose acetylsalicylic acid. When the primary tumor or a metastasis could be measured by ultrasonographic techniques, we observed, on average, a decrease of tumor volume of approximately 25% in a week. We also observed a consistent increase in splenic blood flow that was interpreted in the context of generalised immune system activation and allowed to assess the degree of responsiveness of the individual patient. The results reported here are consistent with the results previously described in the experimental animal harbouring a human hepatocellular carcinoma as well as with the results reported for neoadjuvant chemotherapy. OA-protein complexes are bound to play a leading role in cancer therapy thanks to selectivity of antitumoral effects, absence of any side effects, safety and oral availability. We hypothesise that OA-GcMAF, combines the known anticancer effects OA-protein complexes with the well established immune stimulating effects of GcMAF.

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Keywords

  • GcMAF
  • Oleic Acid
  • Advanced Cancer
  • Integrative Immunotherapy
  • Ultrasonography