Immunological Processes in Cancer: A Link Between Inflammation and Immunity
Vanessa Jacob Victorino, Isabela Casagrande Jeremias and Anne Karine Martins Assunção
DOI : 10.3844/ajisp.2014.189.201
American Journal of Immunology
Volume 10, 2014
Cancer is a worldwide issue and one of the most relevant death causes in child and adults. There are several causes that can lead to cancer development. It is well known that inflammation is one known hallmark of cancer and it favors tumor cells growth. Several alterations in immunological and inflammatory processes are caused in response to tumor presence and both innate and adaptive immunity have effective mechanism to destroy tumor cells. Nevertheless, distinct tumor types developed mechanisms to evade anti-tumor immunological responses. Here, we revise researches regarding inflammation and immune response during cancer development, as well as cancer signaling pathways and immunotherapy that have been performed in Brazil. The better understanding of the mechanisms regarding cancer and immunological processes is of huge importance and it may support the development of new cancer targets.
© 2014 Vanessa Jacob Victorino, Isabela Casagrande Jeremias and Anne Karine Martins Assunção. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.