American Journal of Immunology

Immunomodulatory and Antioxidant Properties of Kaurenoic Acid on Macrophages of BALB/c in Vitro

Juliana Aparecida Macri, Suelen Santos da Silva, Milena Menegazzo Miranda, Natalia Yoshie Kawakami, Thiago Hideki Hayashida, Tiago Bervelieri Madeira, Suzana Lucy Nixdorf, Vinicius Ricardo Acquaro Junior, Sérgio Ricardo Ambrósio, Waldiceu Aparecido Verri Jr, Rubens Cecchini, Ivete Conchon-Costa, Nilton Syogo Arakawa and Wander Rogério Pavanelli

DOI : 10.3844/ajisp.2014.183.188

American Journal of Immunology

Volume 10, 2014

Pages 183-188

Abstract

Kaurenoic acid has been displaying anti-inflammatory effect described in different models. However, the per se immunomodulatory effects of kaurenoic acid remain to be investigated. Thus, the immunomodulatory and antioxidant effects of kaurenoic acid were investigated in vitro on peritoneal macrophages from BALB/c mice. Kaurenoic acid induced per se the production of pro-inflammatory cytokines such as TNFα, IL-1β and IFN-γ while also increased the levels of IL-10. There was also reduction of NO production and induction of anti-oxidant profile. Therefore, in addition to inhibiting inflammation, kaurenoic acid presents immunomodulatory effects per se.

Copyright

© 2014 Juliana Aparecida Macri, Suelen Santos da Silva, Milena Menegazzo Miranda, Natalia Yoshie Kawakami, Thiago Hideki Hayashida, Tiago Bervelieri Madeira, Suzana Lucy Nixdorf, Vinicius Ricardo Acquaro Junior, Sérgio Ricardo Ambrósio, Waldiceu Aparecido Verri Jr, Rubens Cecchini, Ivete Conchon-Costa, Nilton Syogo Arakawa and Wander Rogério Pavanelli. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.