Immunological Response in Bovine Lymph Nodes Stimulated with Subunits Vaccines
Gabriel Andres Tafur Gomez, Marlene Isabel Vargas, Joaquin Hernan Patarroyo Salcedo, Elisangela Neves de Souza, Sidimar Sossai, Leandro de Arujo, Ana Paula Peconik and Karlos Henrique Martins Kalks
DOI : 10.3844/ajisp.2013.48.57
American Journal of Immunology
Volume 9, 2013
The vaccination process belongs to the public health intervention methodologies that help prevent infections. Vaccinations performed successfully in the history of medicine reported the significance of this procedure to increase the quality of life, prevent zoonoses and improve animal production. Vaccine emergence remained without exact rules for a long time, maintaining a close relationship with pathogens. However, subunit vaccines, with a difference from the classical idea of protective immunity with microorganisms showed it is possible to trigger T-dependent responses with peptide, revealing new rules for vaccine development. This vaccination process starts by the modulation chance of adaptive immune response through peptide sequences process by APCs for immune synapse formation interceded for pMHC-TCR as a scaffold to T cells priming. In this way the immunological signal triggered by immune synapses is amplified in lymph nodes. As a consequence, T and B cells modulated by peptide activity interact between the B cell follicles region and T cell aggregates, which constitute the paracortical region of secondary lymphoid tissue to form connate unions as a prerequisite for clonal amplification and subsequent immunological memory. Indicating the knowledge of the mechanisms of immune response generated by peptides immunization is essential for understanding modulation, amplification and immune protection as demands for good subunits vaccine.
© 2013 Gabriel Andres Tafur Gomez, Marlene Isabel Vargas, Joaquin Hernan Patarroyo Salcedo, Elisangela Neves de Souza, Sidimar Sossai, Leandro de Arujo, Ana Paula Peconik and Karlos Henrique Martins Kalks. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.