American Journal of Immunology

Role of Galphaq Containing Protein in Immune Regulation

Yuan Liu, Lu Gan and Guixiu Shi

DOI : 10.3844/ajisp.2012.154.165

American Journal of Immunology

Volume 8, Issue 4

Pages 154-165


G proteins, one of the most important transmembrane signal transducers, contain four subfamilies. Gαq is the α subunit of Gq protein subfamily. The Gαq containing protein initially attracted attention for its physiological significance is in cardiovascular system. In recent years, its role in immune regulation has been indicated. Studies domenstrated that Gαq plays crucial role in regulating both innate and adaptive immune cells function and it is involved in the development of autoimmune disease. In this review, we summarized recent data in the role of Gαq containing protein in regulating immune cells function and the possible mechanisms.


© 2012 Yuan Liu, Lu Gan and Guixiu Shi. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.