Evaluating the Effect of Booster Dose of Hepatitis B Vaccine in Low-and Non-Responders Healthcare Workers and the Role of some Host-Related Factors
Mojtaba Varshochi and Mehdi Haghdoost
DOI : 10.3844/ajisp.2011.24.28
American Journal of Immunology
Volume 7, 2011
Problem statement: Hepatitis B comprises one of the major health problems worldwide. Health Care Workers (HCW) are a group at risk for Hepatitis B Virus (HBV) infection. Infection with hepatitis B virus has become a vaccine-preventable disease. Vaccination against Hepatitis B Virus infection (HBV) is safe and effective. The aim of this study is evaluation the immunologic response of booster dose of Hepatitis B vaccine in none and low responder health care workers and effects of some host-related factors. Approach: In a cross sectional descriptive analytic study carried out on the medical staff of Tabriz Shahid Madani Hospital in 2009-2010, we evaluated the immunologic response of booster dose of Hepatitis B vaccine in none and low responder health care workers and effects of some host-related factors. Results: Of 331 studied health care workers, 123 people (37.2%) were male and 208 people (62.8%) female. The mean antibody titer in the studied medical staff was 304.07±199.98 IU L-1 in the range of 0-1000 and median of 330. Dividing the antibody titer into three groups of "no response" (Titer<10 IU L-1), "Low response" (Titer10-100 IU L-1) and "Good response" (Titer>100 IU L-1) revealed that from 331 studied staff, 31 people (9.4%) were in "no response" group, 40 people (12.1%) in "Low response" group and 260 people (78.59%) in "Good response" group and after one booster dose of vaccine in none and low responder group, 7 people (2.1%) were in "no response" group, 5 people (1.5%) in "Low response" group and 319 people (96.4%) in "Good response" group. Conclusion: One booster dose of vaccine in people with low and none Response to hepatitis B vaccination cause to significantly increase of antibody titer so that, Good response rate increase from 78.5-96.4% and low response rate decrease from 12.1-1.5% and none response rate decrease from 9.4-2.1%. Use one booster dose of vaccine recommended in people with antibody titer blow 100.
© 2011 Mojtaba Varshochi and Mehdi Haghdoost. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.