American Journal of Infectious Diseases

Endotoxin Activity Assay: An Experience of a Southern-Italy Hospital

Linda Degl’Innocenti, Flaviano Di Paola, Rizzo Marianna and Gerardino Amato

DOI : 10.3844/ajidsp.2014.164.166

American Journal of Infectious Diseases

Volume 10, Issue 4

Pages 164-166

Abstract

Endotoxin activity assay is a novel and rapid test capable of differentiating Gram-negative sepsis from infections carried by other bacteria. The test, moreover, represents a useful tool in the management of the septic patient. We show the data collected during a 6-year period experience, related to samples from septic patients admitted in ICU; for each patient we performed an EAA test and a blood culture with an automated system. Our aim was to evaluate the effectiveness of the EAA test, alone or in combination with blood cultures, in ICU setting. Our experience confirms that the measure of the endotoxin levels, along with the execution of a traditional blood culture, provides a useful tool in the management of the critical patient. The high predictive negative value of the EAA test, moreover, allow to rule-out a Gram-negative bloodstream infection.

Copyright

© 2014 Linda Degl’Innocenti, Flaviano Di Paola, Rizzo Marianna and Gerardino Amato. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.