American Journal of Infectious Diseases

The Flavonoid, Quercetin, Inhibits HIV-1 Infection in Normal Peripheral Blood Mononuclear Cells

Madhavan P.N. Nair, Zainulabedin M. Saiyed, Nimisha H. Gandhi and C. N. Ramchand

DOI : 10.3844/ajidsp.2009.135.141

American Journal of Infectious Diseases

Volume 5, Issue 2

Pages 135-141

Abstract

Problem statement: Flavonoids and related polyphenols, have been known to possess cardioprotective, anti-tumor, anti-inflammatory, anti-allergic and anti-viral activities. Previous studies have shown that flavonoid, quercetin significantly downregulates expression of pro-inflammatory cytokines in cultured cells via modulation of NFκB and p38MAPK signaling pathways. In the current study, we hypothesize that quercetin exerts anti-HIV activity by differential modulation of pro-and anti-inflammatory cytokine expression in normal PBMCs. Approach: Cultures of PBMC received either different concentrations of quercetin (1-50

Copyright

© 2009 Madhavan P.N. Nair, Zainulabedin M. Saiyed, Nimisha H. Gandhi and C. N. Ramchand. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.