American Journal of Infectious Diseases

Intrinsically Unstructured Proteins: Potential Targets for Drug Discovery

Pathan Salma, Chintan Chhatbar and Sriram Seshadri

DOI : 10.3844/ajidsp.2009.126.134

American Journal of Infectious Diseases

Volume 5, Issue 2

Pages 126-134


Problem statement: The function of a protein is dependent on its three-dimensional structure. However, numerous proteins lacking intrinsic globular 3D structure under physiological conditions had been recognized. These proteins are frequently involved in some of the most critical cellular control mechanisms and it appears that their rapid turnover, aided by their unstructured nature in the unbound state, provides a level of control that allows rapid and accurate responses of the cell to changing environmental conditions. Approach: A significant number of proteins known to be involved in protein deposition disorders were now considered to Be Intrinsically Unstructured Proteins (IUPs). For example, A


© 2009 Pathan Salma, Chintan Chhatbar and Sriram Seshadri. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.