American Journal of Infectious Diseases

Anti-Platelet and Anti-Endothelial Cell Autoantibodies in Vietnamese Infants and Children with Dengue Hemorrhagic Fever

Nguyen Thanh Hung, Nguyen Trong Lan, Yee-Shin Lin, Chiou-Feng Lin, Le Bich Lien, Kao-Jean Huang, Trai-Ming Yeh, Do Quang Ha, Vu Thi Que Huong, Lien-Cheng Chen, Lam Thi My, Jyh-Hsiung Huang, Ching-Chuan Liu and Huan-Yao Lei

DOI : 10.3844/ajidsp.2008.41.49

American Journal of Infectious Diseases

Volume 4, Issue 1

Pages 41-49

Abstract

Dengue hemorrhagic fever (DHF) is a serious public health problem. Increased vascular permeability and thrombocytopenia are the hallmarks of DHF. The mechanisms involved in DHF/Dengue shock syndrome (DSS) pathogenesis is not fully understood. This study gives evidence of the presence of antibodies which cross-reacted with platelets, and endothelial cells in the sera of Vietnamese infants and children with DHF/DSS. The anti-platelet, anti-endothelial cell IgM levels were higher in the sera of DHF/DSS infants and children, compared with controls. However, the levels of these autoantibodies were not correlated with the severity of DHF (non-shock DHF vs DSS). The antiplatelet, and anti-endothelial cell autoantibodies may play a role in the pathogenesis of DHF/DSS in infants and children with predominantly primary, and secondary dengue infections, respectively. The epitopes shared by surface molecules of platelets and endothelial cells and dengue virus antigens need to be identified and avoided in designing the safe candidate vaccines.

Copyright

© 2008 Nguyen Thanh Hung, Nguyen Trong Lan, Yee-Shin Lin, Chiou-Feng Lin, Le Bich Lien, Kao-Jean Huang, Trai-Ming Yeh, Do Quang Ha, Vu Thi Que Huong, Lien-Cheng Chen, Lam Thi My, Jyh-Hsiung Huang, Ching-Chuan Liu and Huan-Yao Lei. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.