Research Article Open Access

The Effect of a 4th Generation-Cephalosporin Introduction upon the Incidence of Multidrug-Resistant Gram-Negative Bacteria in a Non-Teaching Hospital

Guilherme Henrique Campos Furtado1, Luciana Baria Perdiz1 and Eduardo Alexandrino Servolo Medeiros1
  • 1 Federal University of São Paulo, Brazil

Abstract

Problem statement: Antimicrobial resistance is a worrisome situation in hospitals around the world and the misuse of certain classes of antimicrobials has contributed for this situation. Approach: We performed a prospective surveillance study on the incidence of multi-drug resistant bacteria before (phase 1) and after (phase 2) the introduction of a 4th-generation cephalosporin in a non-teaching hospital. Results: There was a significant reduction in the incidence of Enterobacter species (from 1.3 isolates per 100 patient-days to 0.39 isolates per 100 patient-days, p = 0.01) between the two periods. We also observed a reduction in the consumption of ceftazidime (from 64.3 DDD per 1000 patient-days to 29.6 DDD per 1000 patient-days, p = 0.002) and ceftriaxone (from 323.9 DDD per 1000 patient-days to 246.2 DDD per 1000 patient-days, p = 0.01). Conclusion: The introduction of a 4th-generation cephalosporin in our setting resulted in an important reduction in the incidence of Enterobacter species.

American Journal of Infectious Diseases
Volume 4 No. 4, 2008, 267-271

DOI: https://doi.org/10.3844/ajidsp.2008.267.271

Submitted On: 2 February 2009 Published On: 31 December 2008

How to Cite: Furtado, G. H. C., Perdiz, L. B. & Medeiros, E. A. S. (2008). The Effect of a 4th Generation-Cephalosporin Introduction upon the Incidence of Multidrug-Resistant Gram-Negative Bacteria in a Non-Teaching Hospital. American Journal of Infectious Diseases, 4(4), 267-271. https://doi.org/10.3844/ajidsp.2008.267.271

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Keywords

  • 4th generation-cephalosporin
  • incidence
  • multidrug-resistant
  • Gram-negative bacteria