American Journal of Infectious Diseases

Correlation of IFN-Inducible Protein 10 Levels in Sera with Disease Severity and Clinical Outcome of the Dengue Patients

Ying-Ray Lee, Nguyen-Thanh Hung, Ching-Chuan Liu, Kao-Jean Huang, Huan-Yao Lei, Yee-Shin Lin, Jen-Reng Wang, Trai-Ming Yeh, Shun-Hua Chen and Hsiao-Sheng Liu

DOI : 10.3844/ajidsp.2008.18.21

American Journal of Infectious Diseases

Volume 4, Issue 1

Pages 18-21

Abstract

Dengue Virus (DV) infection may cause life-threatening Dengue Hemorrhagic Fever (DHF) and Dengue Shock Syndrome (DSS). Although many cytokines involved in the pathogenesis of DHF/DSS have been reported, the expression status of IFN-inducible protein-10 (IP-10) in dengue patients is still unknown. This is the first report to unravel that IP-10 level was significantly elevated in the sera of Dengue Fever (DF) patients. However, the level declined while the disease proceeds to severe DHF/DSS, which is different from the expression profiles of other DV related cytokines in the patients. IP-10 may be used to monitor the severity of dengue disease.

Copyright

© 2008 Ying-Ray Lee, Nguyen-Thanh Hung, Ching-Chuan Liu, Kao-Jean Huang, Huan-Yao Lei, Yee-Shin Lin, Jen-Reng Wang, Trai-Ming Yeh, Shun-Hua Chen and Hsiao-Sheng Liu. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.