American Journal of Infectious Diseases

High Case-Fatality Rate of Adults With Dengue Hemorrhagic Fever During An Outbreak In Non-Endemic Taiwan: Risk Factors For Dengue-Infected Elders

Ching-Chuan Liu, Kao-Jean Huang, Mei-Chih Huang, J.-J. Lin, S.-M. Wang, Jen-Jou Liu, Jih-Jin Tsai, Jyh-Hsiung Huang, Yee-Shin Lin, Hsiao-Sheng Liu, Trai-Ming Yeh and Huan-Yao Lei

DOI : 10.3844/ajidsp.2008.10.17

American Journal of Infectious Diseases

Volume 4, Issue 1

Pages 10-17

Abstract

In 2002, a dengue outbreak occurred in Taiwan with 5336 confirmed cases, 242 DHF and 21 death, the case fatality rate reached 8.7% (21/242). The demographic data of these age-specific dengue patients showed that dengue virus infection caused symptom primarily occurred in adults. A comparative analysis of clinical and laboratory data for DF, DHF/DSS and fatal DSS found that high fatality from dengue infection was associated with the following patient conditions: (1) age above 55 years, (2) underlying diseases with hypertension, chronic renal insufficiency, or diabetes, (3) abnormal thrombocytopenia, APTT and PT prolongation, low hematocrit (<30%) and leukocytosis, (4) abnormal elevation of AST, ALT and BUN. In a non-endemic area like Taiwan, dengue should be considered as an adult infectious disease and the dengue-infected elders will have higher morbidity or mortality.

Copyright

© 2008 Ching-Chuan Liu, Kao-Jean Huang, Mei-Chih Huang, J.-J. Lin, S.-M. Wang, Jen-Jou Liu, Jih-Jin Tsai, Jyh-Hsiung Huang, Yee-Shin Lin, Hsiao-Sheng Liu, Trai-Ming Yeh and Huan-Yao Lei. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.