Research Article Open Access

Abnormal Glucose Regulation and Treatment Strategies for Insulin Resistance HIV-Infected Patients

Steven Grinspoon1
  • 1 ,
American Journal of Infectious Diseases
Volume 2 No. 3, 2006, 184-186

DOI: https://doi.org/10.3844/ajidsp.2006.184.186

Submitted On: 12 July 2006
Published On: 30 September 2006

How to Cite: Grinspoon, S. (2006). Abnormal Glucose Regulation and Treatment Strategies for Insulin Resistance HIV-Infected Patients. American Journal of Infectious Diseases, 2(3), 184-186. https://doi.org/10.3844/ajidsp.2006.184.186

Abstract

HIV-infected patients receiving highly active antiretroviral therapy often demonstrate abnormalities in glucose regulation, in association with changes in fat distribution[1,2]. In the majority of cases, these abnormalities are best characterized by insulin resistance and impaired glucose tolerance, rather than overt diabetes mellitus and fasting hyperglycemia. Insulin resistance may result from direct effects of antiretroviral therapy, changes in fat distribution or abnormal regulation of fat metabolism and adipocytokines. Use of insulin sensitizing agents may be rationale to reduce cardiovascular risk and improve related metabolic and body fat abnormalities in HIV-infected patients.

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Keywords

  • HIV-infected patients
  • abnormalities
  • insulin resistance
  • glucose regulation