American Journal of Biochemistry and Biotechnology

CD2 Shown to Facilitate CD4+ Cell Differentiation during Visceral Leishmaniasis, a Receptor Based Study

Sukrat Sinha, Shanthy Sundaram, Sanjiva Bimal, Shubhankar Kumar Singh and Pradeep Das

DOI : 10.3844/ajbbsp.2015.214.220

American Journal of Biochemistry and Biotechnology

Volume 11, Issue 4

Pages 214-220

Abstract

This study addressed the role of CD2 on CD4+ T helper cells in relation to the TCRVα11 and CD70 in two groups of BALB/c mice viz control and infected (1×107 L. donovani promastigotes). The results showed with the downregulation of CD2 expression there is a pronounced decrease of TCRVα11 and CD70 on CD4+ cells in mice. An insight into the behavior of the cytokines viz IL-2, IFN-γand TNF-α also showed disturbance in the concurrent efficiency of these cells in responding to the Leishmania donovoni infection. Hence it can be interpreted that probably CD2 plays an important role during maturation steps of CD4+ T cell differentiation during VL infection.

Copyright

© 2015 Sukrat Sinha, Shanthy Sundaram, Sanjiva Bimal, Shubhankar Kumar Singh and Pradeep Das. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.