Gene Transfer Vector Derived from Jembrana Disease Virus: A Review
Asmarani Kusumawati, Tenri A. Wanahari, Pudji Astuti, Basofi A. Mappakaya and Wasito
DOI : 10.3844/ajbbsp.2015.176.181
American Journal of Biochemistry and Biotechnology
Volume 11, Issue 3
The etiological agent of Jembrana disease is a virus which was accordingly named Jembrana Disease Virus (JDV). JDV was a member of the family of Retroviridae, of the subfamily of lentiviruses. As a member of the lentivirus, JDV has general property to integrate their genome into the chromosomal DNA of the host-cells. It is one of their common properties which is not shared by simple retroviruses such as murine leukimia virus or avian sarcoma virus. Lentiviruses are highly species-specific and share the property of replicating in dividing and non-dividing terminally differentiated cells. JDV-based gene transfer vector which had been developed is appeared to possess a broad tropism and a unique capacity of mediating efficient gene transfer. This review summarize JDV-based viral vector system that has been developed. The main principles and components of JDV viral gene transfer system and its implication in the future research will be discussed.
© 2015 Asmarani Kusumawati, Tenri A. Wanahari, Pudji Astuti, Basofi A. Mappakaya and Wasito. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.