RCMV ALL-03 Model and Study of CMV Pathogenesis in Congenital Infection
Ashwaq Ahmed Abdullah, Krishnan Nair Balakrishnan, Yusuf Abba, Faez Firdaus Jesse Abdullah, Zeenatul Allaudin Nazariah, Rasedee Abdullah, Noordin Mohamed Mustapha and Mohd-Azmi Mohd-Lila
DOI : 10.3844/ajavsp.2015.170.186
American Journal of Animal and Veterinary Sciences
Volume 10, Issue 3
Cytomegalovirus (CMV) is one of the most commonly studied members of the Herpesviridae family. So far several strains have been identified but human CMV (HCMV) remains the most important due to its ability to infect humans and also cross the placenta causing neonatal infection and mortality. However, there are several limitations in the study of this strain which includes availability and use of model animals. Although strains such as Rhesus CMV (RhCMV), Guinea pig CMV (GPCMV) and Rat CMV (RCMV ALL-03) have been shown to cross the placenta and exhibit similar pathogenesis to HCMV, only RCMV ALL-03 can be conveniently used without much limitations as guinea pigs are resistant to antiviral drugs, while rhesus monkeys are seropositive, considered costly and have ethical use restrictions. We therefore propose the use of RCMV ALL-03 as a model for the study of CMV infection.
© 2015 Ashwaq Ahmed Abdullah, Krishnan Nair Balakrishnan, Yusuf Abba, Faez Firdaus Jesse Abdullah, Zeenatul Allaudin Nazariah, Rasedee Abdullah, Noordin Mohamed Mustapha and Mohd-Azmi Mohd-Lila. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.