American Journal of Applied Sciences

Study of Modified Oral Minimal Model using n-Order Decay Rate of Plasma Insulin for the Oral Glucose Tolerance Test in Subjects with Normal, Impaired and Diabetic Glucose Tolerance

Agus Kartono, Egha Sabila Putri, Ardian Arif Setiawan, Heriyanto Syafutra and Tony Sumaryada

DOI : 10.3844/ajassp.2017.426.435

American Journal of Applied Sciences

Volume 14, Issue 4

Pages 426-435

Abstract

In this present study, the modified Oral Minimal Model (OMM), with secretion of insulin from pancreas was assumed that the insulin decay rate was not always a ?rst-orderly process in the Oral Glucose Tolerance Test (OGTT), had been developed to study Normal Glucose Tolerance (NGT), Impaired Glucose Tolerance (IGT or pre-diabetes) and type 2 Diabetes Mellitus (T2DM) subjects. The modified OMM model was used to assess physiological functions which were insulin sensitivity (SI) and glucose effectiveness (SG) from the OGTT data. The results of the modified OMM model fit to the measured glucose and insulin concentration-time profiles in the OGTT process of the subjects. The single-step ?tting process to optimize the real pAarameters of the SI and SG index from the experimental data using the modi?ed OMM. Our results showed that all NGT subjects had higher the SI and SG index than all IGT and T2DM subjects following the OGTT process. Basal and large peak glucose were lower in all NGT subjects than in all IGT and T2DM subjects. Insulin extraction was lower in all subjects with T2DM but was almost similar for the NGT and IGT subjects. The averaged correlation between measured and this present model, commonly called R2 value, showed that these four cases were 0.96 which indicated good agreement.

Copyright

© 2017 Agus Kartono, Egha Sabila Putri, Ardian Arif Setiawan, Heriyanto Syafutra and Tony Sumaryada. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.