American Journal of Applied Sciences

A New Proposed Statistically-Derived Compromise Cut-off CD4 Count Value for HIV Patients to Start using ARVs

Maria Mokgadi Lekganyane and Solly Matshonisa Seeletse

DOI : 10.3844/ajassp.2016.853.859

American Journal of Applied Sciences

Volume 13, Issue 7

Pages 853-859


The study investigated the relationship between statistical outliers and the inconsistent values of the CD4 count recommended for starting the Antiretroviral Therapy (ART) by HIV-positive patients. Low CD4 counts imply a low immune system. It could be due to AIDS existence or closeness to death. An effective treatment to curb HIV impact is ART, which is recommended for low CD4 counts. However, countries differ in the values used. Developed nations recommend start of ART when the CD4 is still high in order to curb its development. Poor countries use very low CD4 counts. Some countries keep changing the CD4 value for this purpose. The problem is that when CD4 counts are too low, HIV may already be too advanced, making it difficult to save the patient from progression to full AIDS. There should be CD4 values derived using scientific methods to assist in standardizing the CD4 count value for ART commencement. Using a retrospective single-site cohort study design, the study analyses the CD4 counts using robust statistical methods together with conventional statistical methods to study outliers and then derive a compromise CD4 count value that could serve as the standard cut-off starting point for using ART. The CD4 count confidence limits showed outliers to be above 300 cells/mm3. The lower bound of 0 cannot happen to any living person. The 300 upper bound is a value within the manageable outliers that has not reached critical HIV state. However, this value is near risky CD4 count values. The CD4 count of 300cells/mm3 indicates deteriorating HIV. If it is set as the starting point of taking ARVs, the patients involved can be saved from reaching painful states of lower CD4 counts.HIV patients’ immune systems at this level can still be boosted without them showing physical weakness from eye inspection.


© 2016 Maria Mokgadi Lekganyane and Solly Matshonisa Seeletse. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.