American Journal of Applied Sciences

Fine Needle Aspiration Cytology Evaluation for Classifying Breast Cancer Using Artificial Neural Network

Nor Ashidi Mat Isa, Esugasini Subramaniam, Mohd Yusoff Mashor and Nor Hayati Othman

DOI : 10.3844/ajassp.2007.999.1008

American Journal of Applied Sciences

Volume 4, Issue 12

Pages 999-1008

Abstract

Thirteen cytology of fine needle aspiration image (i.e. cellularity, background information, cohesiveness, significant stromal component, clump thickness, nuclear membrane, bare nuclei, normal nuclei, mitosis, nucleus stain, uniformity of cell, fragility and number of cells in cluster) are evaluated their possibility to be used as input data for artificial neural network in order to classify the breast precancerous cases into four stages, namely malignant, fibroadenoma, fibrocystic disease, and other benign diseases. A total of 1300 reported breast pre-cancerous cases which was collected from Penang General Hospital and Hospital Universiti Sains Malaysia, Kelantan, Malaysia was used to train and test the artificial neural networks. The diagnosis system which was developed using the Hybrid Multilayered Perceptron and trained using Modified Recursive Prediction Error produced excellent diagnosis performance with 100% accuracy, 100% sensitivity and 100% specificity.

Copyright

© 2007 Nor Ashidi Mat Isa, Esugasini Subramaniam, Mohd Yusoff Mashor and Nor Hayati Othman. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.