Intranasal Administration of Quercetin Liposome Decreases Anxiety-like Behavior and Increases Spatial Memory
Jintanaporn Wattanathorn, Wathita Phachonpai, Aroonsri Priprem and Saengrawee Suthiparinyanont
DOI : 10.3844/ajabssp.2007.31.35
American Journal of Agricultural and Biological Sciences
Volume 2, 2007
At present, the effects of quercetin liposome on anxiolytic activity and cognitive function are unclearly known. In this study, male Wistar rats were administered quercetin liposome via intranasal route once daily continually for 4 weeks. The anxiolytic activity and cognitive enhancing effect were determined after single administration, 1, 2, 3 and 4 weeks of treatment using elevated plus maze test and Morris water maze test respectively. The results showed that quercetin liposome significantly increased both number of opened arm entry and time spent in the opened arm. In addition, the quercetin liposome also decreased escape latency and increased retention time markedly. Therefore, our results demonstrated the anxiolytic activity and cognitive enhancing effect of quercetin liposome and suggested that it might be used as a novel therapeutic strategy for anxiety disorder and cognitive deficit condition.
© 2007 Jintanaporn Wattanathorn, Wathita Phachonpai, Aroonsri Priprem and Saengrawee Suthiparinyanont. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.